Meta-analysis has developed over time as a way to deal qualitatively with varying study results ( O'Rourke, 2007). What should be done if only small trials of possibly low quality are available? When should we perform meta-analysis? Should we accept a combination of observational and randomized studies in meta-analyses? What can we do when multiple meta-analyses are published within a short time-period? A Short History Furthermore, the main points raised by the authors of the Opinion paper ( Simón and Bellver, 2014) will be addressed. In this Editorial, we will discuss the use and pitfalls of aggregate meta-analyses. What is going on? Are meta-analyses not as useful as we thought they would be? Are the included studies not good enough? But, as the critics rightfully point out, studies that include meta-analyses are often not without biases.
Meta-analyses-attacking authors in essence argue that meta-analyses should be faultless while meta-analyses are considered to be highest in the evidence-based pyramid. The authors use the meta-analyses that have been published on the value of endometrial scratching in IVF as an example.
In the present issue of Human Reproduction another example of negative publicity toward meta-analyses is published in the form of an Opinion paper ( Simón and Bellver, 2014). Two years ago systematic reviews and meta-analyses, and more specifically Cochrane reviews, were critiqued ( Humaidan et al., 2012 Humaidan and Polyzos, 2012). This is perfect for video shooters who love to shoot a lot of action.There seems to be a growing negativity toward meta-analyses. But I do know the fast readout speed of the sensor makes the camera less subjective to the rolling shutter effect. I don't know enough about video capabilities to give an opinion about the Sony a1. It shoots video in 8K, and there are lots of settings available for video-oriented enthusiasts and professionals. There are more things to tell about the Sony a1. But if you need a small aperture and the light is bad, be prepared for possibly failed autofocus. Most of the time, you will open the aperture when the environment is dark. I have run into situations when the autofocus fails to focus at all.
You may even get in a situation when the camera is hunting for focus. If you run into a situation when you need to focus in a dark environment with a small aperture, the camera will sometimes fail to recognize faces or eyes. But if you want to use a large depth of field in a dark environment, it may fail on you. Under normal conditions, the AF works perfect.
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